The association between PON1 gene polymorphisms (Q192R and L55M) and nephrotic syndrome in Iraqi children
نویسندگان
چکیده
Background: The role of paraoxonase 1 enzyme (PON1) and its single nucleotide polymorphisms (SNPs) in children with nephrotic syndrome (NS) has been reported previously different ethnic racial groups divergent results. human PON1 gene contains two coding region leading to isoforms. Objectives: aim the present study was find out association between (Q192R L55M) their relation serum activity as well lipid profile tests (total cholesterol, TC; triglycerides, TG; high-density lipoprotein HDL-c; low-density LDL-c) NS. Methods: This included a total 80 participants (40 NS age group 2-14 years 40 sex-matched healthy controls). were measured samples all participants. genotype determined by PCR-restriction fragment length polymorphism (PCR-RFLP) for both alleles (192 55) SNPs. Results: Our findings showed that mean levels (TC, TG, significantly increased patients when compared controls (p<0.05), while HDL-c concentration decreased than controls. Also, had lower concentrations regardless Q192R L55M polymorphisms. Moreover, homozygous RR SNP 192 MM 55 frequent Conclusions: results support presence higher
منابع مشابه
Effect of cigarette smoking on paraoxonase 1 activity according to PON1 L55M and PON1 Q192R gene polymorphisms.
OBJECTIVE This study aims to investigate the effect of cigarette smoking on paraoxonase 1 (PON1) activity according to PON1 L55M and PON1 Q192R gene polymorphisms. MATERIALS AND METHODS Our sample included 300 voluntary subjects: 138 nonsmokers and 162 current smokers aged 38.47 ± 21.91 and 35.55 ± 16.03 years, respectively. PON1 activity was determined by kinetic methods. L55M and Q192R gene...
متن کاملParaoxonase (PON1) L55M and Q192R polymorphisms in major depression and bipolar affective disorder
Background: Oxidative and nitrosative stress pathways, along with immune-inflammatory response, might play an important role in the pathogenic mechanisms underlying major depression and bipolar disorder. Objective: The aim of the present study is to investigate paraoxonase 1 polymorphisms and its correlations with disease parameters in patients with major depression and bipolar affective disord...
متن کاملFrequency of the Q192R and L55M polymorphisms of the human serum paraoxonase gene (PON1) in ten Amazonian Amerindian tribes
Human serum paraoxonase (PON1) is an esterase associated with high density lipoproteins (HDLs) in the plasma and may confer protection against coronary artery disease. Serum PON1 levels and activity vary widely among individuals and populations of different ethnic groups, such variations appearing to be related to two coding region polymorphisms (L55M and Q192R). Several independent studies hav...
متن کاملAssociation of Homocysteine, Asymmetric Dimethylarginine and L55M and Q192R Polymorphisms of Paraoxonase-1 Gene with Preeclampsia
Objective: Preeclampsia is a major cause of maternal and fetal mortality worldwide. A reliable test that would identify the "at risk" group of pregnant women is not available. Homocysteine and ADMA have been shown to be elevated in disorders characterized by endothelial dysfunction including preeclampsia. Paraoxonase 1 is though to influence serum homocysteine and to play a role in preeclampsia...
متن کاملAssociation of paraoxonase-1(Q192R and L55M) gene polymorphisms and activity with colorectal cancer and effect of surgical intervention.
BACKGROUND Colorectal cancer (CRC) is a leading cause of cancer-related death. Oxidative DNA damage may contribute to cancer risk and the antioxidant paraoxonase is one endogenous free radical scavenger in the human body which could therefore exert an influeence. PURPOSE Aim of this study was to determine the role of serum arylesterase (ARE) and paraoxonase 1(PON1) activities in CRC patients ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Baghdad journal of biochemistry and applied biological sciences
سال: 2021
ISSN: ['2706-9907', '2706-9915']
DOI: https://doi.org/10.47419/bjbabs.v2i03.55